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How do swimming sperm cells and ovulated egg cells recognize each other and bind together? Despite substantial research, this question has been somewhat of a mystery for the past thirty plus years. The answer, just in, may be a certain protein in the egg shell or zona pellucida. This soft, glassy layer binds sperm, allows one to enter and then blocks out all others. It appears that sperm bind to specific sugars associated with a particular zonal protein. Sperm-egg binding abnormalities are especially seen among infertility patients and are thought to be a reason for unexplained infertility as well as failed ovulation induction and intrauterine insemination IUI cycles.
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World's largest sperm bank moves to UCF area

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Binding “Mr. Right”: How Sperm Get into the Egg: Center for Reproductive Medicine: Fertility Clinic

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Timing May Be Everything: A Study on Sperm Quality Suggests Diminished Period of Abstinence

Recent clinical research from Doctors Da Li and XiuXia Wang of Shenyang Hospital, published in the journal Molecular and Cellular Proteomics, shows both sperm quality and reproductive outcomes are improved when semen is provided after just hours of abstinence. The prevailing conventional wisdom in reproductive medicine is that limiting sexual activity between conception efforts can improve chances of pregnancy success. This research involved nearly couples to determine if decreasing abstinence time could change their success rates. Prior studies from this lab had shown that semen produced shortly after ejaculation within approximately three hours had faster and more motile sperm than if abstention had been several days.
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